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Is Vitamin C the Most Important Vitamin For You?

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“There are more than ten thousand published scientific papers that make it quite clear that there is not one body process (such as what goes on inside cells or tissues) and not one disease or syndrome (from the common cold to leprosy) that is not influenced – directly or indirectly – by vitamin C.” Drs Emanuel Cheraskin, Marshall Ringsdorf and Emily Sisley

To demonstrate how being low in even one nutrient can affect your entire body, I’d like to give myself as an example. Even as a nutrition researcher and recognizing deficiencies from thousands of programs for our clients at Swanson Health Center, there is always something to learn. I eat well, exercise, sleep and try to balance work and play. But sometimes, certain events transpire that you glance over as symptoms of stress, not realizing more precisely it is your inability to withstand stress from a deficiency.

Last year, I had a series of things happen that I attributed to stress. I injured my back in a yoga class, my eyes were bothering me when I used the computer and got glasses, my gums started receding, and just recently I started to develop environmental allergies for the first time after moving to a new climate. I assumed everything was related to over-working (and overtraining), and that the allergies were something that apparently everyone has in this area. But I also thought about how environmental allergies really don’t make sense in an evolutionary context, and since nature always provides what we need in each environment, it would stand to reason that vitamin C and flavonoids like quercetin from plants would counterbalance the reaction to the very allergens they produce.

I had been taking what I considered a low dose of whole food vitamin C (about 150mg for acerola cherry, camu camu and rose hips) with a vitamin pack, thinking that this was a sufficient amount with my diet. When I started reading 1) how quickly vitamin C is depleted post-harvest making my whole foods vitamin C questionable 2) how vitamin C is depleted in high amounts by stress, pollution, and exercise, and that in most food it is basically depleted from storage, processing, and cooking – I started to second guess myself.

It wasn’t until I started to experiment with 3-4 grams of vitamin C to see if I could eliminate new environmental allergies that I had never had, that I started seeing results. My cough and allergy symptoms disappeared. I felt relaxed with a strong balanced sense of well-being despite a very stressful time of family issues. My body felt stronger and more resilient with faster recovery times. My gums looked healthier, my eyes felt stronger and I was able to maintain all of these things with a 3-gram dose. I started to wonder if vitamin C was the most important vitamin I should be taking.

How Were These Symptoms All Related to Vitamin C?

  • Vitamin C is necessary for the correct synthesis of collagen, and it helps to maintain healthy collagen. Collagen is the glue that holds your body together, and without healthy collagen, you will begin to fall apart. Vitamin C strengthens the tendons through collagen synthesis, and high dose vitamin C has been found to accelerate healing of the Achilles tendon.
  • The vitamin C concentration in the lens of the eye is one of the highest of any human tissue.
  • Vitamin C has a high concentration in the adrenal glands and is used up rapidly during times of emotional stress.
  • The link between gum health and vitamin C has long been established.
  • Vitamin C works as an antihistamine against environmental allergens.
  • Through genetic testing at Nutrition Genome, I was able to discover an increased need for vitamin C. 

Here are some other ways YOU could be deficient in vitamin C, and how it can help you stay well:

  • Vitamin C is depleted during a fever, viral illness, antibiotics, cortisone, aspirin and pain medicines.
  • Sugar and vitamin C use the same transport mechanism, which excess sugar overrides and causes deficiency.
  • Environmental toxins such as DDT, petroleum products, carbon monoxide, exposure to heavy metals such as lead, mercury or cadmium deplete vitamin C rapidly. This means just our environment is depleting our vitamin C. Adequate vitamin C intake removes toxic metals such as aluminum, mercury, and lead from the body.
  • After exposure to toxic chemicals, natural killer cell function is decreased significantly (common after chemotherapy). One study found that at a dose of 60mg per kilogram of body weight (4000mg for a 150lb person), vitamin C enhanced natural killer cell function ten-fold in 78% of patients.
  • Sulfa antibiotics increase elimination of vitamin C from the body by two to three times the normal rate.
  • Extensive research shows that adequate vitamin C reduces the risk of cancer, heart disease, colds, flu, cataracts, hypertension and even depression.
  • Vitamin C speeds wound healing, helps keep the body in good repair, slows the aging process and extends life itself. A lack of vitamin C results in tiny cracks in the walls of the blood vessels, which makes the body produce more cholesterol to fill in the cracks. Vitamin C keeps blood vessels strong, reducing circulating cholesterol, while also clearing the inner walls of fat deposits. 
  • Vitamin C is also very safe; negative effects from overdosing have never been observed. Only contraindications are high amounts of oxalic acid in the urine, anemia from pyruvate kinase and G6PD deficiencies, iron metabolism disorder causing increased iron storage, sickle cell anemia.

We Once Produced Our Own Vitamin C!? How Did We Lose our Vitamin C Mojo?

What really peaked my interest about vitamin C is that we can’t produce it while some animals can, and every brightly colored berry and vegetable that contains vitamin C appear to be nature’s way of attracting us to this molecule. Like water, neither plants or animals can live without vitamin C, making it one of the most important vitamins for survival, especially for preventing infection.

We have all probably heard the story of the sailors that got scurvy while on the sea due to a lack of fruits and vegetables and was quickly remedied by the additions of citrus to the boat. Cases of scurvy are very serious and has accounted for millions of lost lives. But if we go back a little further, we find out something very interesting about vitamin C. The arthropoid primates were able to synthesize vitamin C. That’s right, the hominids (estimated to be 2.3 to 2.4 million years old) that include the modern human are a part of the arthropoid primate pack.

It is thought our ancestors lost this ability roughly 25 million years ago. In fact, many species, such as anthropoid primates, teleost fishes, guinea pigs, as well as some bat and Passeriformes bird species, have lost the capacity to synthesize it. This compound is synthesized by the large majority of vertebrate and invertebrate species, including our faithful companions, the dog and cat. When’s the last time your dog or cat caught a cold?

The reason we lost it has to do with an evolutionary gene mutation, much like photolayse that use to protect us from the sun. As this seems like a mutation that would have seemed unfavorable for survival, it somehow became a dominant trait and remains a mystery. From my own studies about how diet has changed our skin color, I would place my bet on the climate changing the available plant life, increasing vitamin C consumption and causing a genetic mutation that told the body it is no longer needed. Yet over hundreds of millions of years, the majority other animals did not lose this ability; most likely due to not obtaining enough from the diet to trigger a mutation. Was our intake that high?

Do We Need Higher Doses of Vitamin C for Optimal Health?

All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident. -Arthur Schopenhauer 

It was estimated by The New England Journal of Medicine in 1985 that the Paleolithic diet provided approximately 400mg of vitamin C to our ancestors. Today the RDA is 90mg a day for adult males and 75mg a day for adult females. Put on your thinking cap for a second and think about that. We had 400mg from freshly harvested plants, organ meats, and zero pollution. Today, most of the vitamin C is almost absent from our foods due to storage and preparation, while we have satan’s easter basket of chemicals in the water, air, and soil.

What about athletes? According to Dr. Colgan, Ph.D., who researched vitamin C absorption rates in athletes, he reported a variance with individuals ranging from 100-1000%. That’s 900 to 9,000mg for males. Guinea pig studies have found that there is a twenty-fold range in the vitamin C needs of individual guinea pigs for optimal health and that the individual variations in humans are probably just as great. Based on stress, illness, heavy metals, 150lbs of sugar consumption per year, air pollution, water contamination, exercise, genetic variants and medications, how much do you think most of us need today?

How Three Scientists Arrived at the Same Conclusion

Linus Pauling is one of only two people who won two Nobel Prizes in different fields, and one of them was for chemistry. He is often referred to as one of the most brilliant scientists of our time, yet his research on vitamin C is what brought him the most controversy – and the most opposition from people that apparently have done something more impressive than win two Nobel Prizes. The first was the physician Dr. Victor Herbert refuting his recommendation for the common cold, asking for research to back up his claims. Pauling sent 4 randomized double-blind clinical studies – like he asked – from which Dr. Herbert allegedly got flustered, took his ball and went home.

Linus Pauling started out taking 3,000mg and worked up to 18,000mg of vitamin C, after receiving a letter and attached study from a biochemist showing how 3,000mg of vitamin C could extend his life 25 years or more. I had the pleasure of meeting Dr. Zelek Herman on the Stanford Campus, who worked with Linus Pauling for the last 15 years of his life. He claimed that Pauling was one of the most brilliant men he had met. After talking with Dr. Herman about his work with Pauling, speaking two of the six different languages he spoke as other people he knew approached him, I started to think that he was one of the most brilliant men I had met.

Pauling based his own intake of vitamin C on several factors, including the amount synthesized by animals that are able to do so, the amount consumed in the diet by wild animals that are biologically closely related to humans, and the estimated intake by our Paleolithic ancestors. He claimed he used to get colds often, but once he started taking vitamin C they never came back. He lived until he was 94 and obviously did something right. Dr. Herman continues the regiment of 10,000mg of vitamin C a day.

Raymond Francis, a chemist from MIT and author of Never Be Sick Again, saved his own life with vitamin C and came up with the theory that there is only one disease, two causes (deficiency and toxicity) and six pathways. To this day, Francis takes 10,000-12,000mg of vitamin C daily.

The truth of the matter is that every clinical practitioner I have spoken with that has decades of experience, has recommended dosages in the range of 2000mg to 6000mg orally for various disorders and recommending high dose vitamin C IV’s for cancer. For oral doses, bowel tolerance is often used to determine when the level is too much. There is no shortage of anecdotal cases of success to back up these dosages, and, of course, it is difficult to prove what you prevented for those being proactive. Obviously, something is missing between the research and practical application with oral vitamin C.

What Do the Studies on Vitamin C Really Say?

There are currently 52,119 studies on vitamin C! I have never seen so much controversy and conflicting studies and research as I have with vitamin C. If you are limiting yourself to a Google search on vitamin C studies, you are going to be on a wild ride of confusion and possibly convinced that anything over 200mg is a waste. But you would be doing yourself a great disservice, especially if you do not take the time to see why the poor design of many vitamin C studies has stifled larger research on an inexpensive solution to possibly improving the health of the entire human population.

For the sake of not making this article ten pages in length, I will not bore you with an analysis of each study. You can read many of these in the book Ascorbate: The Science of Vitamin Cvitamin c (not boring to us science nerds), Curing the Uncurable and some fascinating double blind studies in the book How to Live Longer and Feel Bettervitamin c by Linus Pauling. Here a few to peak your interest:

Vitamin C and The Common Cold and Flu

In a study of 463 students that used 1,000 milligrams every hour for 6 hours, then 3 times daily after that, reported flu and cold symptoms in the test group decreased 85% compared with the control group after the administration of megadose Vitamin C.

Vitamin C and Cardiovascular Disease

For those interested in vitamin C and cardiovascular disease, you will find that from 1990-2000 there is only 1 study that shows a beneficial response to a dose of less than 500mg of vitamin C and 3 studies with no response. You will also find 30 studies with a beneficial response over 500mg, and 4 studies with no response. So why do we highlight the negative studies and disregard higher doses again?

How Negative Vitamin C Studies Can Be Poorly Designed

What I will say is that it appears very clear that many of the negative studies:

  • Used too low a dose to find any significant value
  • Used too small of a sample population 
  • Did not understand the mechanism and half-life of vitamin C, and therefore limited it to one daily dose when multiple doses should have been used throughout the day
  • Did not take into the account the numerous health variables that change vitamin C status, and an RDA for an entire population cannot not be effectively established based on the mechanism of vitamin C and bio-individuality
  • Makes you wonder if cheap, simple and unable to be patented vitamin C is a bigger threat to pharmaceutical companies than is publicized

The Most Accurate Understanding of Vitamin C

The Dynamic Flow Model put forth by Dr. Steve Hickey and Dr. Hillary Roberts addresses the flaws in vitamin C research, while also giving the best explanation as to the full mechanism of vitamin C in the body. “It is biologically useful to have a dynamic flow through the body, even though not all the ascorbate is absorbed. During times of stress or infection, ascorbate absorption is increased; the surplus dietary ascorbate then acts as a reservoir upon which the body can draw without delay.”

In animals when levels are low, they make more. Humans cannot do this, and continually need to fill the reservoir for protection against free radical tissue damage that can happen continually throughout the day from our lifestyle, environment and exercise frequency. Therefore it stands to reason a surplus of vitamin C would be better than a deficiency, with the dosage being spread out throughout the day.

How to Choose the Right Vitamin C

There are three simple rules for choosing a vitamin C product.

1. It should be 100 percent L-ascorbic acid and NOT 50 percent D-isoascorbic acid, the isomer. D-isoascorbic acid is considered biologically inert, an irritant and may even interfere with vitamin C metabolism.

2. It should be fully reduced. This means it is 100 percent in the anti-oxidant form, not pro-oxidant form which will damage tissues.

3. It should be from non-GMO corn (more of an environmental bonus than change to the final product) or non-corn sources like potatoes, beets or tapioca.

There does not appear to be any difference or advantage with flavonoids for increasing absorption, however, they do have other important health qualities and come with vitamin C foods known as vitamin P. There are some indications that Ester-C should be avoided.

Regarding Lypo-spheric C: Raymond Francis states that it is a solution to a problem that doesn’t exist (vitamin C getting into the tissues), however the claim from Lypo-Spheric C is that it allows more in. He also states that dissolving ascorbate in water to make tiny nano-particles will cause the dissolved oxygen in the water to oxidize the C. The form of ascorbate presumably used in this product is calcium ascorbate that consists of D, L-ascorbate, meaning it is 50% D-ascorbate and only 50% L-ascorbate. Dr. Steve Hickey is the creator of Lypo-Spheric C, and from what I’ve read has done the best job of elucidating the mechanism of vitamin C and breaking down poor studies. One is a chemist from MIT and the other a Medical Biophysicist from the University of Manchester. We may need a one on one match in the lab with these titans to know the truth.

Regarding Emergen-C: A recent lab testing in Canada found that it contained only 332mg of vitamin C, not 1,000mg, and has over 50% sugar from purified fructose.

Here Are Products that Follow These Guidelines: To Your Health!

Avoid products that contain sodium benzoate and vitamin C together. In certain conditions, sodium benzoate combines with ascorbic acid to create benzene, a known cause of cancer.

1. C-Salts Buffered Vitamin C

This is a corn free, non-GMO buffered vitamin C with a long successful 35-year history. It has been recommended in the past by Linus Pauling and Dr. Weil and is by far the best formula on the market. I have been using this one for a month now, and I can say that I see a difference in potency compared to other vitamin C products. A buffered vitamin C contains calcium, magnesium, potassium and zinc to buffer ascorbic acid, making it easy on the stomach. It is much easier to use higher dosages or smaller dosages for children as well. Note that the serving size is 1 tsp., 4,000mg. Dose accordingly.

2. Thorne Research Vitamin C with Flavonoids

I emailed Thorne Research and had the 3 rules confirmed with a medical professional, and it contains the flavonoids or vitamin P. The flavonoids (rutin, hesperidin, and quercetin) play important roles for lowering inflammation. Hesperidin in particular, is a natural aromatase inhibitor. They also stated that there are no corn allergens present with the finished product, however, I have had clients with corn sensitivities who did react.

3. Viva Labs Vitamin C with Bioflavonoids and Rose Hips

Viva Labs uses Quali-C qualified L-ascorbate from Scotland – which is attractive when 90 percent is produced in China – and is non-GMO. It also contains bioflavonoids.

4. Doctor’s Best Vitamin C 1000mgvitamin c

vitamin c

The Vitamin C Foundation approves products that are DSM Quali-C qualified L-ascorbate from Scotland.

5. Perque Potent C Guardvitamin c

vitamin c

I use to have this as Beyond Health’s Vitamin C, however, I have since discovered that Perque creates these for Beyond Health under a private label, and Beyond Health then increases the price. Not cool. So I found the original Perque vitamin C that is much cheaper, and as advertised, 100 percent L-ascorbate, pH balanced, buffered and corn free.




3. Primal Panacea by Thomas E. Levy MD

4. How to Live Longer and Feel Better by Linus Pauling

5. Ascorbate: The Science of Vitamin C by Dr. Steve Hickey and Dr. Hilary Roberts

6. The Vitamin C Foundation

34 Responses to Is Vitamin C the Most Important Vitamin For You?

  • I just had a hystarectomy and i lost my gall bladder in 2005 and I had back surgery in 1995 and may be facing more surgery in the upcoming year. I have a food allergy to soybean. My son is a carrier hemochromatosis disease. My boyfriend has low testosterone. We love food but what foods should we eat to keep us healthy sine we all have health problems now?

    • Hi Donna,

      All of you have different needs, and I couldn’t do a very good job of making recommendations without a full analysis and consultation at

      On the home page of PaleoEdge, if you scroll down you will see the general overall list of foods I recommend. On the heart disease article, I have a food list at the bottom that is even more specific for what to avoid found here.

      For low testosterone, I have an article that shows you how to raise it naturally found here.

      Let me know if I can be of any more help.

  • I agree with you 100% of the “poorly designed studies.” I’ll take that further and say many are “designed to fail” due to an agenda. For instance, 1 study shown in Reader’s Digest claimed “Vit C Did Nothing For Colds Or Flu”. When I looked at the study it showed participants took a measly 300mg once a day, lol.

    Anyone who knows anything about Vit C, knows it has a short half life and therefore must be taken several times throughout the day to elevate the blood levels. Otherwise it’s not going to affect disease much.

    • Hi Chris,

      Exactly! We also all have different requirements, and I have seen nothing but positive results when using the right dosage of vitamin C.

  • Today is the first time I have come across your site & really enjoy the in depth look at many of these supplements & reports. Thank you. I have a family friend who is purchasing his supplements from gnc & I don’t know much about their stuff. They gave him a gnc 1,000 vit c with bioflavonoids & rose hips time released pills. He just had appendix removed & found out his gallbladder is working at 22% so I’m helping him review his diet. (He is also taking healthy delights chewable 5,000mcg biotin which seems extreme to me!!!
    I currently take hakala c-tab 1,000mg … If I feel run down I found it helpful to take 2-3 pills. How do you feel about the 2 brands? Thank you for your time.

    • Hi Riva,

      Glad you are enjoying the articles! As a general rule, I don’t hold a high opinion of GNC brand supplements. I think a lot of them are poorly made and formulated. For the vitamin C, it is worth calling GNC to confirm if it is 100 percent L-ascorbate, and not 50 percent D-ascorbate. The same with Hakala, which is not a company I am not familiar with. I would agree with you that 5,000mcg of biotin is extreme, and potentially damaging.

  • Hey Alex, i purchased c salts and was reading up on a ascorbic flush. What is your opionion on it? Thanks so much!

    • Hi Dylan,

      I have only read about the vitamin C flush from Raymond Francis/Perque and Dr. Levy, and heard anecdotal accounts. The closest I have come to something similar is using 1,000mg on the hour in the beginning stages of a cold/flu to knock it out. I would like to find more research on what exactly is occurring during the flush because it sounds very interesting for detoxification purposes.

  • Alex, Hi! It’s Sue from the office. This is most interesting; I hadn’t seen it before. My question is regarding the chewable Cs from Trader Joe’s. They are 500mg of ascorbic acid and sodium ascorbate. The key words are sort of there (?), but the “L” is missing and I don’t know where the sodium fits in. Are they any good at all? It’s hard to be a layman in such an important field.

    • Hi Sue,

      Great to hear from you! I sent an email with some questions to Trader Joes regarding this product. As soon as I hear back I will let you know.

    • Hi Sue,

      I just heard back from Trader Joes and they confirmed it is L-ascorbate. My only criticism would be the use of sugar in the product.

  • Hi Alex,

    Thank you for all the great articles!
    One question…
    How is the product below? It uses sodium ascorbate instead of L-ascorbic acid.

    NutriBiotic, Sodium Ascorbate, Crystalline Powder

    • Hi Robin,

      This is still in the form of L-ascorbate but is mixed with sodium bicarbonate which lowers the acidity. It looks high quality, so I would be surprised if it wasn’t 100% L-ascorbate. If you are doing megadoses of vitamin C, be aware that this could give you a larger dose of sodium.

  • I use Natural Factors Vitamin C 1000 mg [ ascorbic acid ] citrus bioflavonoids 100 mg, rosehip 4 to 1 extract 100 mg tablets. Is this a good product?

    • Hi Keith,

      Yes, I got it verified that is 100% L-ascorbate. They also have a buffered calcium ascorbate powder that is only available in Canada.

  • Hi, just read your article thank you for all the good information. I was wondering if you have any take on children taking vitamin C? How much especially during this cold/ flu season?

    • Hi Renee,

      I think it is fine for children to take vitamin C. The amount ranges based on age/weight. Typically, this amount may be between 200mg-500mg up to age 12.

  • Regarding Lypo-spheric C – Since writing this article in 2014, do you now have any further opinions on lypo-spheric C and claims of higher levels of absorption?

    • Hi Bridget,

      Great question. At the time of this article, only one pilot study with two subjects had been done with 5g of lipo-spheric vitamin C vs. regular vitamin C. That study didn’t find any difference. However, just recently, a study was conducted with 11 subjects and 4g of liposomal vitamin C, regular vitamin C, intravenous vitamin C and a placebo. The intravenous vitamin C had the highest absorption, then Lypo-spheric, regular and placebo. They demonstrated Lypo-spheric did achieve higher absorption rates. However, this study was funded by the company that makes Lypo-spheric vitamin C.

      At this point, I think we need independent studies to confirm these results and see what physiological changes are taking place between the different types of vitamin C. I’m intrigued myself and there is some potential here, but I’d like to read more independent documented research.

  • Hi Alex,
    I can see your point and thank you VERY much for the information. Latter is pretty rare, when trying to explain what vit c is and what it might do. However i am stil mighty confused about the intake of ascorbic acid. I found two studies claiming that vit c is bad for humans in certain conditions, and i would REALLY love to debunk those to calm myself :). I know the pointers you gave in your article, but can you have a quick look at those studies and tell me what you think?

    I guess, again they used a crappy form of vit c? I just like to debunk stuff :).
    Also: can you recommend a german vit c brand which is a little cheaper? (Bonus question 🙂 )

    All the best!Thanks

    • Hi again,
      it really looks like the studies were mediocre at best. I cannot believe, how many worries this created in me. That is not even scientific.
      Further reading here, german site but english test:

      • Hi Simon,

        Yes, it is important to look at the details of the vitamin C studies. The outlier studies tend to grab headlines or cause concern even though the evidence from multiple studies point to the contrary. We often find out that they are fundamentally flawed and a meta-analysis is required.

        Regarding the second study you posted about vitamin C as a chemopreventative, I’m not able to dig deeper because I can’t view the whole study. We do know now that vitamin C in the IV form is most effective for cancer. It has been shown to induce the pro-oxidant hydrogen peroxide into cancer cells, similar to the action of chemotherapy but without harming other cells. I explore the mechanism in this article: There is often a simplistic view of antioxidant and pro-oxidant reactions in the body, and we are finding that both are necessary for optimal health in balance.

        As far as a German brand of vitamin C, I’m not familiar with what is available to you. I would be happy to review any you are interested in using.

        • Hi Alex,
          many thanks again for looking into those studies. You were absolutely right, those studies cannot be taken serious. I am glad you could calm my mind :). I am definatly convinced to try out some extra Vitamin C now next to my PHD (Perfecthealthdiet) way of eating. Paul Jaminet advised ,like you, to get some more Vitamin C as a sup.
          I also found out, that it is pretty cheap to order your recommended brands to germany. They are also superiour anyway. If someone else is concerned: I never found information what kind of ascorbic acid is beeing used. Maybe there is no need for specification that wide in europe. Same goes for the usage of maltodextrin, because there is no need for the producers to inform about that either.
          So thank you Alex. I am set :).

          Wish you all the best. Thanks for all the informations. Cheers from germany.

          again :).

  • I have been a part of the MAG forum on Facebook, which is spearheaded by Morley Robbins. He advises his thousands of followers to only use whole food vitamin C. He said that using the synthetic vitamin C effects ceruloplasmin negatively. He strongly advises against it. Have you heard of this? And if so, do you think he’s reading the research wrong? If you go do is website that be you can see that he studies deeply and profoundly before speaking out. He thinks a lot of our issues are iron excess, and he also writes a lot about vitamin, or hormone D, and also advises people not supplement vitamin D or calcium. When I saw that first products you listed and your like of it, I noticed it had calcium in it. So I’m pretty freaked out about supplementing calcium and anything that is not whole food vitamin C after having followed him for quite a while in this group. I have just been diagnosed with ALS, and it seems like nothing I’ve done has halted my decline. I have purposely staid away from high doses of vitamin C and am wondering if I’ve done myself a disservice. Any help you haven’t this apartment would be much appreciated.

    • Hi Linda,

      I would recommend reviewing the books Ascorbate: The Science of Vitamin C by Dr. Steve Hickey and Dr. Hilary Roberts, and Curing the Incurable by Dr. Levy to make your own conclusions regarding the research of synthetic vitamin C. About 20% of ALS cases are connected to mutations in the SOD1 zinc/copper gene. SOD1 is a major copper-binding protein and regulates copper homeostasis in the cell, and a mutation is believe to affect toxicity. Copper is bound to ceruloplasmin and in mice studies, copper is elevated in the spinal cord from the overexpression of SOD1. If ALS is directly linked to glutamate toxicity, that could occur from copper toxicity. Vitamin C in larger doses would then help chelate excess copper while boosting GABA, the antagonist to glutamate.

      Iron excess and iron deficiency can both be problematic and increase DNA damage. Balance is key. I would say I see more issues today related to high copper levels. I don’t think small amounts of calcium supplementation are an issue, and only potentially can become an issue when very high doses of calcium are used in relation to low doses of magnesium and K2. Magnesium deficiency would be a bigger concern due to its role in protecting against a glutamate-induced calcium influx into cells. Studies have found that calcium concentration in the gray matter of ALS cases was significantly higher than that of controls, likely from elevated glutamate.

      I’m very sorry to hear about your recent diagnosis. Let me know if you have any questions.

  • Hi Alex, I just found your website and it is good to ind someone who really researches which supplements are truly helping us. Your articles have answered many of my questions re which supplements to choose. i have a question re my dog ( although I know your focus is on humans) My dog has severe allergies/skin condition itching. Do you think Vitamin C in high doses would help her. I know dogs make their own Vit C but her body has been under stress for a long time due to chronic illness. Could she benefit form Vit C and if so what form would best suit her . regards Carolyn

    • Hi Carolyn,

      That is a great question and I wish I could answer it accurately. I’m really not sure if your dog’s allergies and skin condition would benefit from vitamin C IV’s. I think dogs benefit from a lot of things that we do, and there isn’t a placebo effect so you really know when something works! It can’t hurt to try different natural methods.

    • Hi Carolyn,

      Something I would definitely try is dog prebiotics and probiotics if the skin issues are related to the gut function.

  • Hi Alex,
    I was wondering what you thought of Naturelo’s new vitamin C supplement I saw it was added on Amazon. Should I try it or stick with the C-Salts? I’ve been taking the C-Salts for the last few months based off you having it as the top vitamin c supplement =)

    • Hi Jeff,

      It looks like they are using L-ascorbate and acerola, but their explanation says 500mg from acerola cherries. I wonder how much of the L-ascorbate is included because the acerola vitamin C will deplete rapidly. You are still better off with the C-salts in my opinion due to a better stability.

  • What are your thoughts on Shaklee’s Vitamin C?

  • Ho what you think of “Pure Radiance C” from Synergy Company?

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